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Paper | Regular issue | Vol 51, No. 10, 1999, pp.2321-2333
Published online, 1st January, 1970
DOI: 10.3987/COM-99-8584
Chemistry of Indoles Carrying a Basic Function. Part IV. Synthesis of D-Nor- ergoline and Ergoline Ring by Stobbe Reaction

István Moldvai, Eszter Temesvári-Major, Eszter Gács-Baitz, Orsolya Egyed, Ágnes Gömöry, László Nyulászi, and Csaba Szántay*

*Institute of Chemistry, Chemical Research Center, Hungarian Academy of Sciences, H-1525 Budpest , P.O. Box 17, Hungary


Starting from Uhle’s ketone (2), pentacyclic lactone derivatives with D-norergoline ring (13 and 14) have been prepared by an unusual intramolecular Stobbe reaction of a succinic diester derivative (3a). The preparation of ergoline ring (1) itself was also achieved through modification of the reaction conditions.