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■ Synthesis and Reactivity of Some Mannich Bases. VII. Synthesis of 3-(2-Dialkylaminoethyl)-1,2-benzisoxazoles

Eugenia Comanita, Irina Popovici, Gheorghe Roman, Gilles Robertson, and Bogdan Comanita*

*National Research Council of Canada, Institute for Chemical Process and Environmental Technology, Montreal Road Compus, Ottawa, Ontario, K1A 0R6, Canada

Abstract

3-(2-Dialkylaminoethyl)-1,2-benzisoxazoles (2) are accessible by direct cyclization of the corresponding Mannich bases oxime acetates (11) in refluxing benzene in the presence of anhydrous potassium carbonate. The previously known methods for ring closure to 1,2-benzisoxazole were ineffective for this class of pharmacologically relevant compounds.