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Paper | Regular issue | Vol 51, No. 7, 1999, pp.1593-1596
Published online, 1st January, 1970
DOI: 10.3987/COM-99-8554
Synthesis of Cytotoxic Pyrroloquinazolinoquinoline Alkaloid Luotonin A

Zhong-Ze Ma, Yoshio Hano, Taro Nomura,* and Ying-Jie Chen

*Faculty of Pharmaceutical Sciences, Toho University, 2-2-1, Miyama, Funabashi, Chiba 274-8510, Japan


A convenient synthesis of cytotoxic pyrroloquinazolinoquinoline alkaloid, luotonin A (1), was achieved in 3 steps; (i) reaction of anthranilic acid with O-methylbutyrolactim to deoxyvasicinone, (ii) oxidation of deoxyvasiciiione, and (iii) formation of luotonin A by the reaction of vasicinone with anthranyl aldehyde.