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Communication | Regular issue | Vol 51, No. 7, 1999, pp.1499-1502
Published online, 1st January, 1970
DOI: 10.3987/COM-99-8547
First Electrochemical Defluorination in Heterocyclic Chemistry. Mild Cathodic Reduction of Some Fluoroquinolones

Antonella Profumo, Elisa Fasani, and Angelo Albini*

*Department o f Organic Chemistry, University of Pavia, Via Taramelli 10, 27100 Pavia, Italy


Some 7-piperazinoquinolones undergo smooth cathodic defluorination in aqueous buffer (pH 7.2) at -1.35 V vs Ag/AgC1 via an ECE mechanism; a 6-fluoro derivative is reduced, a 6,8-difluoro analogue is selectively reduced at position 8.