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Paper | Regular issue | Vol 51, No. 7, 1999, pp.1573-1583
Published online, 1st January, 1970
DOI: 10.3987/COM-99-8540
Preparation of 4-(2-Aminoethyl)-3,3-dimethyl-2-piperidone Derivatives by Intramolecular Rearrangement of α,α-Dimethyl-4-piperidineacetyl Chloride

Jean L. Binet,* Corinne Grandvincent, and Didier M. Thomas

*Laboratoires Fournier S. A., Groupe Fournier, 50, Rue de Dijon, 21121 Daix, France


Reaction of hindered amines with α,α-dimethyl-4-piperidineacetyl chloride provided 4-(2-aminoethyl)-3,3-dimethyl-2-piperidone derivatives by intramolecular rearrangement of the acid chloride.