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Paper | Regular issue | Vol 51, No. 7, 1999, pp.1563-1572
Published online, 1st January, 1970
DOI: 10.3987/COM-99-8529
An Efficient Synthesis of Ofloxacin and Levofloxacin from 3,4-Difluoroaniline

Javier Adrio, Juan C. Carretero,* José L. García Ruano,* Antonio Pallarés, and Mercedes Vicioso

*Departamento de Química Orgánica, Facultad de Ciencias, Universidad Autónoma de Madrid, Cantoblanco, 28049-Madrid, Spain


The functionalization at either C-2 or C-3 of N-(tert-butoxycarbonyl)-3,4-difluoroaniline based on its ortho-deprotonation under different experimental conditions is described. This kind of products can be readily applied to the synthesis of ofloxacin, levofloxacin and related compounds.