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Note | Regular issue | Vol 51, No. 7, 1999, pp.1625-1630
Published online, 1st January, 1970
DOI: 10.3987/COM-99-8517
Pyridazines, 90. On the Synthesis of Novel 1,2-Diazine Containing Tricyclic Systems: Preparation of Tetraazaphenazines

Gottfried Heinisch, Elisabeth Huber, and Barbara Matuszczak*

*Institute of Pharmaceutical Chemistry, University of Innsbruck, Innrain 52a, A-6020 Innsbruck, Austria

Abstract

Reaction of 6-chloro-N-(3,6-dichloropyridazin-4-yl)-3-(4-methoxy-benzyl-amino)-N-propyl-pyridazine-4-carbox-amide (1) under strong basic conditions or with a weak base at high temperature was found to result in a ring contraction to give two isomeric tetra-aza-phenazines. A tentative mechanism is proposed.