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Note | Regular issue | Vol 51, No. 5, 1999, pp.1119-1124
Published online, 1st January, 1970
DOI: 10.3987/COM-99-8480
Synthetic Studies on Trifluoroacetylindoles

Hitoshi Takami, Hirokazu Koshimura, and Toshiaki Kumazawa*

*Pharmaceutical Research Institute, Kyowa Hakko Kogyo Co., Ltd., Nagaizumi, Shizuoka, 411-8731, Japan

Abstract

Trifluoroacetylindoles were obtained regioselectivcly through the reaction of indolylorganometallic species, prepared by halogen-metal exchange or direct metalation of N-substituted or -nonsubstituted indoles, with TFAA in good yield