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Communication | Special issue | Vol 49, No. 1, 1998, pp.101-104
Published online, 1st January, 1970
DOI: 10.3987/COM-98-S46
Antimalarial Activities in vitro of Homoprotoberberine Derivatives. Design of Novel Antimalarials and Structure-Activity Relationship Analysis

Junji Miyata, Hiromi Nakashima, Hideo Nemoto, Hye-Sook Kim, Yusuke Wataya, and Masataka Ihara*

*Pharmaceutical Institute, Tohoku University, Aobayama, Sendai 980-8578, Japan

Abstract

Antimalarial activities in vitro of homoprotoberberine derivatives against Plasmodium falciparum were examined. It has shown that 9-hydroxy-2,3,10-trimethoxyhomoprotoberberine (10) was the most potent compound and the hydroxyl group at the C-9 position would play a significant role in exhibiting antimalarial activity and selective toxicity.