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Communication | Special issue | Vol 50, No. 1, 1999, pp.71-74
Published online, 1st January, 1970
DOI: 10.3987/COM-98-S(H)46
Synthesis of Functionalized Pyrrolidines from Mesoionic 4-Trifluoroacetyl-1,3-oxazolium-5-olates and Aminomalonate

Masami Kawase,* Hiroshi Miyamae, and Setsuo Saito

*Faculty of Pharmaceutical Sciences, Josai University, 1-1 Keyakidai, Sakado, Saitama 350-0295, Japana

Abstract

Mesoionic 4-trifluoroacetyl-1,3-oxazolium-5-olates (1) undergo tandem addition of aminomalonate to afford 3-amido-4-trifluoromethylpyrrolidin-2-ones (2) in moderate yields.