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Paper | Regular issue | Vol 51, No. 2, 1999, pp.337-344
Published online, 1st January, 1970
DOI: 10.3987/COM-98-8445
Synthesis of Novel Peptidomimetics, Cyclic Hexamers of Unnatural Amino Acids, 2,5-Disubstituted 3-Aminobenzoic Acids

Katsuya Endo* and Hiroyasu Takahashi

*Tohoku Pharmaceutical University, 4-4-1 Komatsushima, Aoba-ku, Sendai 981-8558, Japan

Abstract

Coupling of 3-aminobenzoic acids and cyclization of their peptides have been accomplished, for the first time, using methanesulfonyl chloride. Cylindrical conformations for the 30-membered cyclic hexapeptides, with trans configuration at the amide bonds, are suggested by ROESY study as well as MM calculations.