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Communication | Regular issue | Vol 51, No. 3, 1999, pp.497-500
Published online, 1st January, 1970
DOI: 10.3987/COM-98-8430
Tandem Nucleophilic Reaction Leading to Hydrofurans: Application to One-Pot Synthesis of Antitumor Naphthofuran Natural Product

Hisahiro Hagiwara,* Kouji Sato, Toshio Suzuki, and Masayoshi Ando

*Graduate School of Science and Technology, Nigata University, 8050, 2 no-cho, Ikarashi, Nigata 950-2181, Japan


The reaction of enolates of 1,3-dicarbonyl compounds (1) with 3,4-dibromo-2-butanone (2) afforded hydrofuran derivatives (4) or (5) in the presence of DBU in THF and the reaction was applied to the one-pot synthesis of antitumor naphthofuran natural products (29).