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Note | Regular issue | Vol 51, No. 3, 1999, pp.627-630
Published online, 1st January, 1970
DOI: 10.3987/COM-98-8425
A Convenient and Facile Synthesis of 3-Trifluoromethyl-1,2,5-oxadiazoles with the Use of Silica Gel as an Effective Catalyst

Yasuhiro Kamitori*

*Department of Chemical Science andd Engineerring, Faculty of Engineering, Kobe University, Kobe 657-8501, Japan


Silica gel catalyzed intramolecular dehydration of 1,1,1-trifluoro-alkane-2,3-dione dioximes (2) afforded 3-trifluoromethyl-1,2,5-oxadiazoles (3) in satisfactory yields.