Online article for Non-subscribers

Pay per view

Heterocycles has a pay-per-view service for Non-subscribers.
You will be able to directly purchase the full text article through PayPal.
Your purchased Paper can be downloaded after the payment is completed.
An e-mail will be sent the URL to download the paper.
If you have any questions, please contact:

Price: ¥ 4,400 (Yen only)
Period: This Article can be accessed for 7 days.

Note | Regular issue | Vol 51, No. 2, 1999, pp.379-385
Published online, 1st January, 1970
DOI: 10.3987/COM-98-8410
Syntheses of Various Imidazo[5,1-c][1,2,4]triazole Derivatives Having Potential Biological Activities

Mohamed Abdel Hamid Ismail

*Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ain Shams University, Abbassiya, Cairo, Egypt


The title compounds (5a-f) and (6a-f) were synthesized from the corresponding 4-arylidene-hydrazonoimidazolidines (3a-f) and (4a-f) on treatment with acetic anhydride. The intermediates (3a-f) were obtained by reacting 4-hydrazono-2-thioxoimidazolidines (2a-b) with various aldehydes. The later (2a-b) were resulted by reacting 2,4-dithiohydantoins (1a-b) with N2H4. Methylation of 3a-f gave 4a-f.