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Paper | Regular issue | Vol 51, No. 1, 1999, pp.29-36
Published online, 1st January, 1970
DOI: 10.3987/COM-98-8287
A Mild Method for the Preparation of 8-Substituted Xanthines from 5,6-Diaminouracils

Aline D. de Araujo, Edmond Bacher, F. W. Joachim Demnitz,* and Douglas A. Santos

*Departamento de Química Fundamental, Universidade Federal de Pernambuco, Cidade UniversitÁria, CEP 50.670-901, Recife - PE, Brazil


The Schiff base derivatives (3), prepared from the respective 5,6-diaminouracil (1) and aldehydes can be mildly oxidatively cyclized with m-CPBA in MeCN to afford C-8 substituted xanthines (6).