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Note | Regular issue | Vol 48, No. 9, 1998, pp.1923-1930
Published online, 1st January, 1970
DOI: 10.3987/COM-98-8236
Pyrimidine Derivatives Starting from Dicyanoketene Ethylene Acetal

Zhijun Wang and Richard Neidlein*

*Pharmazeutisch-Chemishces Institut, Ruprecht-Karls-Universität Heidelberg, Im Neuenheimer Feld 364, D-69120 Heidelberg, Germany

Abstract

Dicyanoketene ethylene acetal (1) reacted with substituted guanidines to yield o-aminocyanopyrimidines, which reacted with N,N-dimethylformamide dimethyl acetal to afford N,N-dimethylaminomethyleneaminopyrimidine derivatives. A new approach to pyrimido[4,5-d]pyrimidines from o-aminocyanopyrimidine and N-dichloromethylenedialkyliminium chlorides followed by cyclization with ammonium hydroxide was reported.