Online article for Non-subscribers

Pay per view

Heterocycles has a pay-per-view service for Non-subscribers.
You will be able to directly purchase the full text article through PayPal.
Your purchased Paper can be downloaded after the payment is completed.
An e-mail will be sent the URL to download the paper.
If you have any questions, please contact:

Price: ¥ 4,400 (Yen only)
Period: This Article can be accessed for 7 days.

Note | Regular issue | Vol 48, No. 9, 1998, pp.1923-1930
Published online, 1st January, 1970
DOI: 10.3987/COM-98-8236
Pyrimidine Derivatives Starting from Dicyanoketene Ethylene Acetal

Zhijun Wang and Richard Neidlein*

*Pharmazeutisch-Chemishces Institut, Ruprecht-Karls-Universität Heidelberg, Im Neuenheimer Feld 364, D-69120 Heidelberg, Germany


Dicyanoketene ethylene acetal (1) reacted with substituted guanidines to yield o-aminocyanopyrimidines, which reacted with N,N-dimethylformamide dimethyl acetal to afford N,N-dimethylaminomethyleneaminopyrimidine derivatives. A new approach to pyrimido[4,5-d]pyrimidines from o-aminocyanopyrimidine and N-dichloromethylenedialkyliminium chlorides followed by cyclization with ammonium hydroxide was reported.