Online article for Non-subscribers

Pay per view

Heterocycles has a pay-per-view service for Non-subscribers.
You will be able to directly purchase the full text article through PayPal.
Your purchased Paper can be downloaded after the payment is completed.
An e-mail will be sent the URL to download the paper.
If you have any questions, please contact:

Price: ¥ 4,400 (Yen only)
Period: This Article can be accessed for 7 days.

Paper | Regular issue | Vol 48, No. 9, 1998, pp.1887-1901
Published online, 1st January, 1970
DOI: 10.3987/COM-98-8225
Total Synthesis of Topsentin, Antiviral and Antitumor Bis(indolyl)imidazole

Ikuo Kawasaki, Hideo Katsuma, Yohko Nakayama, Masayuki Yamashita, and Shunsaku Ohta*

*Kyoto Pharmaceutical University, Misasagi, Yamashina-ku, Kyoto 607-8412, Japan


Topsentin (1), which was isolated from marine sponges and has antiviral and antitumor activities, was synthesized via a cross coupling reaction in the presence of palladium catalyst at th 5-position and an acylation at the 2-position of imidazole ring.