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Paper | Regular issue | Vol 48, No. 8, 1998, pp.1609-1622
Published online, 1st January, 1970
DOI: 10.3987/COM-98-8217
Synthesis of Pyridazino[4,5-b]carbazoles as Potential Antitumor Agents

Norbert Haider,* Rami Jbara, Forouzandeh Khadami, and Richard Wanko

*Institute of Pharmaceutical Chemistry, University of Vienna, Währinger Strasse 14, A-1090 Vienna, Austria


The synthesis of a series of new pyridazino[4,5-b]carbazoles (8, 9, 12-14), representing 3-aza analogs of pyrido[4,3-b]carbazole antitumor agents, is described. The key intermediates, d-fused dichloropyridazines of type 5, were subjected to nucleophilic displacement reactions and/or to reductive dehalogenation.