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■ Synthesis of Pyridazino[4,5-b]carbazoles as Potential Antitumor Agents

Norbert Haider,* Rami Jbara, Forouzandeh Khadami, and Richard Wanko

*Institute of Pharmaceutical Chemistry, University of Vienna, Währinger Strasse 14, A-1090 Vienna, Austria

Abstract

The synthesis of a series of new pyridazino[4,5-b]carbazoles (8, 9, 12-14), representing 3-aza analogs of pyrido[4,3-b]carbazole antitumor agents, is described. The key intermediates, d-fused dichloropyridazines of type 5, were subjected to nucleophilic displacement reactions and/or to reductive dehalogenation.