Online article for Non-subscribers

Pay per view

Heterocycles has a pay-per-view service for Non-subscribers.
You will be able to directly purchase the full text article through PayPal.
Your purchased Paper can be downloaded after the payment is completed.
An e-mail will be sent the URL to download the paper.
If you have any questions, please contact:

Price: ¥ 4,400 (Yen only)
Period: This Article can be accessed for 7 days.

Paper | Regular issue | Vol 48, No. 9, 1998, pp.1833-1840
Published online, 1st January, 1970
DOI: 10.3987/COM-98-8216
A Novel Tetracyclic System Containing the 1,2,6-Thiadiazine Ring: Synthesis, Structural Assignment and Tautomeric Studies

Nuria Campillo, Angeles de la Cruz, Pilar Goya, and Juan A. Páez*

*Instituto de Química Médica, C. S. I. C., Calle Juan de Cierva, 3, E-28006 Madrid, Spain


Condensation of 3,4,5-triamino-2H-1,2,6-thiadiazine 1,1-dioxide with phthalaldehyde afforded a tetracyclic system of thiadiazino[3’,4’:4,5]imidazo[2,1-a]isoindole 2,2-dioxide. In order to establish the correct structure it was necessary to use an 15N-labelled thiadiazine derivative as starting material. Ab initio theoretical calculations and the Onsager model have been used to study annular tautomerism in this novel structure.