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Paper | Regular issue | Vol 48, No. 9, 1998, pp.1801-1811
Published online, 1st January, 1970
DOI: 10.3987/COM-98-8208
Five New Withanolides from Withania coagulans

Atta-ur-Rahman,* Muhammad Yousaf, Waseem Gul, Samina Qureshi, M. Iqbal Choudhary, Wolfgang Voelter, Antje Hoff, Fricke Jens, and Aniqa Naz

*International Centre for Chemical Sciences, H. E. J. Research Institute of Chemistry, University of Karachi, Karachi-75270, Pakistan


Phytochemical studies on the whole plant of Withania coagulans have resulted in the isolation of five new withanolides, namely coagulins H, I, J, K and L (1-5). Their structures have been established as (17S,20S,22R)-5α,6β,14α,15α,17,20-hexahydroxy-1-oxowitha-2,24-dienolide (1), (14R,17S,20S,22R)-5α,6β,17-trihydroxy-14,20-epoxy-1-oxowitha-2,24-dienolide (2), (14R,17R,20R,22R)-3β,27-dihydroxy-14,20-epoxy-1-oxowitha-5,24-dienolide (3), (14R,17R,20R,22R)-14,20-epoxy-3β-(O-β-D-glucopyranosyl)-1-oxowitha-5,24-dienolide (4) and (14R,17R,20R,22R)-14,17,20-trihydroxy-3β-(O-β-D-glucopyranosyl)-1-oxowitha-5,24-dienolide (5), respectively on the basis of spectroscopic techniques.