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Note | Regular issue | Vol 48, No. 8, 1998, pp.1669-1672
Published online, 1st January, 1970
DOI: 10.3987/COM-98-8207
Improved Synthesis of Watasenia Preluciferin

Hisae Kakoi and Shoji Inoue*

*Faculty of Pharmacy, Meijo University, 150 Yagotoyama, Tenpaku, Nagoya 468-8503, Japan


On heating a mixture of 2-amino-3-benzyl-5-(p-hydroxyphenyl)pyrazine (2) and a large excess of p-hydroxyphenylpyruvic acid (4) at 130-140 °C in dioxane, without any reductive treatment, Watasenia preluciferin (1) was obtained directly in one batch process in 63 % yield.