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Communication | Regular issue | Vol 48, No. 9, 1998, pp.1739-1745
Published online, 1st January, 1970
DOI: 10.3987/COM-98-8203
Synthesis of Tetrapyrrole Nitrogen Mustards with Potential Anti-tumor Activities

Zhi-Long Chen,* Wei-Qin Wan, Jing-Rong Chen, Fang Zhao, and De-Yu Xu

*Institute of Pharmaceutical Chemistry, Second Military Medical University, 800 Xiang Yin Road, Shanghai 200433, China


Eight porphyrin nitrogen mustards and six meso-tetraphenylporphin nitrogen mustards were synthesized. Most of the compounds possess both the chemotherapeutic and photochemotherapeutic effects on tumor.