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Paper | Regular issue | Vol 48, No. 8, 1998, pp.1593-1597
Published online, 1st January, 1970
DOI: 10.3987/COM-98-8192
Reaction of 1-Benzylindole-2,3-dicarboxylic Anhydride with 3-Bromo-4-lithiopyridine: Formal Synthesis of Ellipticine

Yasuyoshi Miki,* Yoshitaka Tada, and Ko-ichi Matsushita

*Faculty of Pharmaceutical Sciences, Kinki University, 3-4-1, Kowakae, Higashi-Osaka 577-8502, Japan


Reaction of 1-benzylindole-2,3-dicarboxylic anhydride with 3-bromo-4-lithiopyridine gave 2-(3-bromoisonicotinoyl)indole-3-carboxylic acid as the sole product. The indole-3-carboxylic acid could be converted to 6-benzylellipticine quinone in five steps.