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■ Synthesis of Imidazonaphthyridines and -quinolines

Spiros Grivas* and Peter Schuisky

*Department of Organic Chemistry, Södertörn University College, Karolinska Institutet, Novum Research Park, SE-141 57 Huddinge, Sweden

Abstract

Four 2-amino-3-methylimidazo[4,5-b][1,x]naphthyridines, x=5-8 (6-9) have been obtained from aromatic aldehydes (11-14) and 2-amino-1-methyl-2-imidazolin-5-one (15) in one step. The N¹- and N³-methyl isomers of 2-aminoimidazo[4,5-b]quinoline (5 and 10) were prepared from 2-nitrobenzaldehyde via the isolated E-isomers of imidazolin-5-one (17) and imidazolin-4-one (20).