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Paper | Regular issue | Vol 48, No. 8, 1998, pp.1527-1535
Published online, 1st January, 1970
DOI: 10.3987/COM-98-8150
Versatile Synthesis of 2-Aryloxyalkyl-oxirane-2-carboxylate: Syntheses of Ethyl 2-[6-(3-Alkoxyphenoxy)hexyl]oxirane-2-carboxylates

Young-Ger Suh,* Kyung-Hoon Min, So-Young Baek, and Jung-Hyeon Chai

*College of Pharmacy, Seoul National University, Shillim-Dong, San 56-1, Kwanak-Gu, Seoul 151-742, Korea


A versatile synthetic route to 2-aryloxyalkyl-oxirane-2-carboxylates as potential hydroglycemic agent has been developed via combination of dioxirane epoxidation of inactive olefin and facile aryl alkyl ether formation of the labile epoxy alcohol by Mitsunobu reaction.