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Communication | Regular issue | Vol 48, No. 5, 1998, pp.869-873
Published online, 1st January, 1970
DOI: 10.3987/COM-98-8146
Corchorusosides A, B, C, D, and E, New Cardiotonic Oligoglycosides from the Seed of Corchorus olitorius L. (Moroheiya)

Masayuki Yoshikawa,* Toshiyuki Murakami, Hiromi Shimada, Nobuyuki Fukada, Hisashi Matsuda, Yutaka Sashida, and Johji Yamahara

*Kyoto Pharmaceutical University, Misasagi, Yamashina-ku, Kyoto 607-8412, Japan

Abstract

The methanolic extract of the seeds of Corchorus olitorius L. (Moroheiya) was found to show inhibitory effect agatinst Na+,K+-ATPase and positive inotropic activity in the guinea pig isolated atria. Through bioassay-guided separation from the methanolic extract, new cardenolide oligoglycosides called corchorusosides A, B, C, D, and E were isolated together with six known cardenolide oligoglycosides. The structures of new corchorusosides were determined on the basis of chemical and physicochemical evidence. All cardenolide oligoglycosides from the seeds showed potent inhibitory activity against Na+,K+-ATPase, which was equivalent to those of digitoxin and ouabain. The methanolic extract, glycoside fraction, and principal glycoside showed potent acute toxicity by intraperitoneal administration, whereas they showed little acute toxicity by oral administration. Furthermore, by means of HPLC quantitative analysis of the cardiotonic oligoglycosides, it was found that the glycosides mainly distributed in the seeds, while the edible parts such as fresh young leaves and stems contained only trace amount.