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Note | Regular issue | Vol 48, No. 6, 1998, pp.1229-1235
Published online, 1st January, 1970
DOI: 10.3987/COM-98-8130
Pyrrolo[2,3-d][1,2,3]triazoles as Potential Antineoplastic Agents

Alessandra Passannanti, Patrizia Diana, Paola Barraja, Francesco Mingoia, Antonino Lauria, and Girolamo Cirrincione*

*Instituto Farmacochimico, Università Degli Studi di Palermo, Via Archirafi 32, 90123 Palermo, Italy

Abstract

Halonitropyrrole (1a) underwent nucleophilic substitution by substituted benzylamines (7) to give the intermediates (8), which by reduction and diazotization followed by an intramolecular coupling reaction led to derivatives of the title ring system (10).