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Paper | Regular issue | Vol 48, No. 5, 1998, pp.939-947
Published online, 1st January, 1970
DOI: 10.3987/COM-98-8119
Synthesis of Bis(N-methylpyrrole Oligopeptide-linked Hydroxamic Acids) and Effective DNA Cleavage by Their Vanadyl Complexes

Shigeki Hashimoto, Kazuo Yamamoto, Takao Yamada, and Yushin Nakamura*

*Department of Biological Science and Technology, Science University of Tokyo, 2641 Yamazaki, Noda, Chiba 278-8510, Japan

Abstract

Dimeric N-methylpyrrole oligopeptide hydroxamic acids, which are connected at the carboxy termini via an alkylamino tether, have been newly synthesized. The plasmid DNA relaxation assay indicated that vanadyl-mediated DNA cleavage by these molecules is more effective than that by the corresponding monomeric ones. The cleavage activity of the dimeric complexes exhibited a maximum ratio for vanadyl / dimeric compounds of 2 whereas that of the monomeric ones exhibited a ratio of 1. Two vanadyl-hydroxamate complexing moieties are suggested to independently participate in the effective DNA cleavage by the dimeric complexes.