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Note | Regular issue | Vol 48, No. 4, 1998, pp.779-785
Published online, 1st January, 1970
DOI: 10.3987/COM-98-8102
A Convenient One-Pot Synthesis of 6-Trifluoromethylpyridines

Isamu Katsuyama, Seiya Ogawa, Hiroko Nakamura, Yoshihiro Yamaguchi, Kazumasa Funabiki, Masaki Matsui, Hiroshige Muramatsu, and Katsuyoshi Shibata*

*Department of Chemistry, Faculty of Engineering, Gifu University, 1-1 Yanagito, Gifu, Gifu 501-1193, Japan


α,β-Unsaturated trifluoromethyl ketones (1) react with primary enamines (2) such as β-aminocrotononitrile and β-aminocrotonates in the presence of phosphorus oxychloride / pyridine adsorbed on silica gel and manganese dioxide, providing good to high yields of 6-trifluoromethylpyridines (5).