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Paper | Regular issue | Vol 29, No. 5, 1989, pp.865-872
Published online, 1st January, 1970
DOI: 10.3987/COM-98-4809
Synthesis of (—)-3-Butyl-4-hydroxyphthalide

Yoshimitsu Ogawa,* Kunio Hosaka, Masao Chin (Chen Zhengxiong) and Hiroshi Mitsuhashi

*Research Institute for Biology and Chemistry, Tsumura & Co., 3586 Yoshiwara, Ami-machi, Inashiki-gun, Ibaraki 300-1192, Japan


(-)-3-Butyl-4-hydroxyphthalide 1 was first synthesized enantioselectively by using a chiral aryllithium reagent and its absolute stereochemistry at C-3 was determined to be S-configuration.