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Communication | Special issue | Vol 46, No. 1, 1997, pp.87-90
Published online, 1st January, 1970
DOI: 10.3987/COM-97-S30
A Short Path Synthesis of α-Hydroxy Ester from Aldehyde Using (1-Ethoxy-vinyl)lithium and Its Application to the Syntheses of Thymine Polyoxin C and Uracil Polyoxin C

Hiroyuki Akita,* Kimio Uchida, and Cheng Yu Chen

*School of Pharmaceutical Sciences, Toho University, 2-2-1, Miyama, Funabashi, Chiba 274-8510, Japan

Abstract

A short path synthesis of the α-hydroxy esters (4 and 5) from the aldehyde (3) using (1-ethoxyvinyl)lithium and its application to the total syntheses of the pyrimidine nucleoside, thymine polyoxin C (1) and uracil polyoxin C (2), are described.