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Communication | Special issue | Vol 46, No. 1, 1997, pp.45-48
Published online, 1st January, 1970
DOI: 10.3987/COM-97-S17
Synthesis of Both Enantiomers of Acetophthalidin

Hidenori Watanabe, Kanako Uchida, and Takeshi Kitahara*

*Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan

Abstract

Both enantiomers of acetophthalidin, a potent cell cycle inhibitor, were synthesized employing Sharpless asymmetric dihydroxylation as a key step.