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Communication | Special issue | Vol 47, No. 1, 1998, pp.143-148
Published online, 1st January, 1970
DOI: 10.3987/COM-97-S(N)55
A Convenient Synthesis of Fluorine-containing2,5-Epoxynaphth[1,2-b]azepines by Thermally Induced Cyclization of N-Allyl Substituted 2,4-Bis(trifluoroacetyl)-1-naphthylamines

Etsuji Okada,* Takeshi Tomifuji, Hiroshi Tone, Hiroshi Takeuchi, and Masaru Hojo

*Department of Chemical Science andd Engineerring, Faculty of Engineering, Kobe University, Rokkodai-cho, Nada-ku, Kobe 657-8501, Japan


Thermally induced cyclization of N-allyl substituted 2,4-bis(trifluoroacetyl)-1-naphthylamines (4) proceeded easily in refluxing butyronitrile to give the corresponding 7-trifluoroacetyl-5-trifluoromethyl-2,5-epoxynaphth[1,2-b]azepines (5) in excellent yields.