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Communication | Regular issue | Vol 48, No. 4, 1998, pp.617-620
Published online, 1st January, 1970
DOI: 10.3987/COM-97-8089
Synthesis and Antibacterial Activity of New, Non-natural 1β-Methylcarbapenem Bearing a σ-Symmetric Bicyclopyrazoliumthio Group as the Pendant Moiety

Yoshimitsu Nagao,* Satoshi Tamai, Noriko Tanigawa, Shigeki Sano, Toshio Kumagai*, and Ikuo Kishi

*Faculty of Pharmaceutical Sciences, University of Tokushima, Sho-machi, Tokushima 770-8505, Japan


Mercaptobicyclopyrazolium chloride (3) was successfully synthesized starting from pyrazole (4), and then exploited for the synthesis of new 1β-methylcarbapenem (2) which exhibits excellent antibacterial activities.