Online article for Non-subscribers

Pay per view

Heterocycles has a pay-per-view service for Non-subscribers.
You will be able to directly purchase the full text article through PayPal.
Your purchased Paper can be downloaded after the payment is completed.
An e-mail will be sent the URL to download the paper.
If you have any questions, please contact:

Price: ¥ 4,400 (Yen only)
Period: This Article can be accessed for 7 days.

Note | Regular issue | Vol 48, No. 4, 1998, pp.755-767
Published online, 1st January, 1970
DOI: 10.3987/COM-97-8083
Reaction of Proflavine Derivatives with Formaldehyde: Access to Mono- and Bis-(3,4-dihydro[1,3]oxazino)acridines of Pharmacological Interest

Noémie Fixler, Martine Demeunynck,* Alain Duflos, and Jean Lhomme*

*Ledss/UMR 5616, Université Joseph Fourier, 38041 Grenoble cédex 9, France


Proflavine derivatives react with formaldehyde in acidic media to give 3,4-dihydro[1,3]oxazino condensed compounds. Depending on the nature of the solvents and the substituents attached to the exocyclic nitrogens, mono and bis reaction can occur.