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Communication | Regular issue | Vol 48, No. 3, 1998, pp.437-441
Published online, 1st January, 1970
DOI: 10.3987/COM-97-8074
Efficient Phenylsulfenylation and Phenylselenenylation at the 5-Position of Uracil Nucleosides with Disulfide and Diselenide Mediated by [Bis(trifluoroacetoxy)-iodo]benzene

Kyoung Rok Roh, Hye Kyung Chang, and Yong Hae Kim*

*Department of Chemistry, Korea Advanced Institute of Science and Technology, 373-1, Kusung-Dong, Yusung-Gu, Taejon, 305-701, Korea

Abstract

A series of uracil nucleosides reacted with diphenyl disulfide or diphenyl diselenide in the presence of hypervalent iodine reagent, [bis(trifluoroacetoxy)iodo]benzene, in acetonitrile to give the corresponding C-5 phenylsulfenylated or phenylselenenylated products respectively in excellent yields.