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Paper | Regular issue | Vol 48, No. 3, 1998, pp.507-518
Published online, 1st January, 1970
DOI: 10.3987/COM-97-8073
A Synthesis of the Quinolizidine Alkaloids (±)-Lasubine I and (±)-Lasubine II

Valérie Bardot, Daniel Gardette, Yvonne Gelas-Mialhe, Jean-Claude Gramain, and Roland Remuson*

*Laboratoire de Chimie des Substances Naturelle, UMR 6504, Université Blaise Pascal (Clermont-Ferrand), 24, avenue des Landais 63177 Aubiére Cedex, France


A total synthesis of (±)-lasubine I and (±)-lasubine II has been achieved in six steps from a β-hydroxyallylsilane synthon using intramolecular cyclization of allylsilane on N-acyliminium ion as a key step.