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Note | Regular issue | Vol 48, No. 2, 1998, pp.319-328
Published online, 1st January, 1970
DOI: 10.3987/COM-97-8038
Synthesis of 2,4-Diaminoquinazoline Derivatives

Wojciech Zielinski,* Agnieszka Kudelko, and Elizabeth M. Holt

*Instiute of Organic Chemistry and Technology, Silesian University of Technology, ul. Krzywoustego 4, 44-101 Gliwice, Poland


A series of 6- and 7-substituted derivatives of 2-(N,N-diethylamino)-4-(N,N-dimethylamino)quinazoline have been synthesized. The synthesis consists in converting N-phenyl-N’,N’-diethylurea into chloroamidines which are treated with N,N-dimethylcyanamide to 1-chloro-2,4-diaza-1,3-butadiene derivatives, followed by a cyclization to quinazoline derivatives.