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Note | Regular issue | Vol 48, No. 3, 1998, pp.529-536
Published online, 1st January, 1970
DOI: 10.3987/COM-97-8011
2-Haloalkylidenepropanedinitriles in the Synthesis of Fused Pyrimidines

Chaitanya G. Dave* and Rina D. Shah

*Organic Synthesis Laboratory, M. G. Science Institute, P. O. Box 4007, Navrangpura, Ahmedabad 300 009, India

Abstract

A single step synthesis of various heterocycles such as 2-cyano-5-phenylpyrrolo[1,2-a]quinazolines (6), 5-phenyl-7-cyano-8,9,10,11-tetrahydroindolo[1,2-a]quinazoline (7), 2-cyanocyclopenta[4,5]thieno[3,2-e]pyrrolo[1,2-a]pyrimidin-5(4H)-ones (9) and 4-(2-amino-3-cyanopyrrolo-1-yl)-5-carbethoxythiazole-2-thiones (10) have been reported using 2-haloalkylidenepropanedinitriles (1) and (2) with 5-substitued 2-aminobenzophenones (3), 2-amino-3-carbethoxycyclopenta[4,5]thiophenes (4) and 3-substituted 4-amiono-5-carbethoxythiazole-2-thiones (5) respectively.