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Communication | Regular issue | Vol 45, No. 12, 1997, pp.2317-2320
Published online, 1st January, 1970
DOI: 10.3987/COM-97-7971
The Novel Preparation Methods of 5-Substituted Methyl-1-azabicyclo-[3.3.0]octane

Mitsuru Oka, Kunihisa Baba, Tomoo Suzuki, and Yukiharu Matsumoto*

*Drug Discovery Research Department, Sanwa Kagaku Kenkyusho, 363 shiosaki, Hokusei-cho, Inabe-gun, Mie, 511-04, Japan

Abstract

5-Substituted methyl-1-azabicyclo[3.3.0]octane, which is a useful intermediate for drugs, was readily synthesized from 1,7-dichloro-4-heptanone without isolating unstable intermediates.