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Paper | Regular issue | Vol 48, No. 4, 1998, pp.641-655
Published online, 1st January, 1970
DOI: 10.3987/COM-97-7949
Synthesis of 2,3-Disubstituted 4-Oxoquinolines and 3-Substituted Fused 4-Oxoquinolines

Hamad Z. Alkhathlan* and Khalid A. Al-Farhan

*Department of Chemistry, King Saud University, P.O. Box2455, Riyadh-11451, Saudi Arabia


Seven 2,3-disubstituted 4-oxoquinolines were prepared via two methods. In the first one 2,3-disubstituted 4-oxoquinolines were prepared via the condensation of 2-amino-α-cyanoacetophenone with substituted phthalic anhydrides, while in the second method the fused isoindolo[2,1-a]quinolines and pyrrolo[1,2-a]quinolines were first prepared and then converted to 4-oxoquinolines. X-Ray crystal structure analysis of ethyl 2-[3-cyano-4-oxo-2-quinolyl]benzoate is preported.