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Paper | Regular issue | Vol 45, No. 11, 1997, pp.2185-2195
Published online, 1st January, 1970
DOI: 10.3987/COM-97-7936
Novel Formation and Crystal Structure of 2-(2,2,2-Trifluoroethylidene)-6-trifluoro-methyl-2,3-dihydro-4H-1,4-oxazin-3-ones from N-Acetyl-N-alkyl-α-amino Acids

Masami Kawase,* Setsuo Saito, Hiroyuki Kikuchi, and Hiroshi Miyamae

*Faculty of Pharmaceutical Sciences, Josai University, 1-1 Keyakidai, Sakado, Saitama 350-0295, Japana

Abstract

The title compounds (2a-g) were formed from N-acetyl-N-alkyl-α-amino acids (1a-g) on treatment with trifluoroacetic anhydride in the presence of pyridine. The structure of the product (2a) was determined by single crystal X-Ray analysis.