Online article for Non-subscribers

Pay per view

Heterocycles has a pay-per-view service for Non-subscribers.
You will be able to directly purchase the full text article through PayPal.
Your purchased Paper can be downloaded after the payment is completed.
An e-mail will be sent the URL to download the paper.
If you have any questions, please contact:

Price: ¥ 4,400 (Yen only)
Period: This Article can be accessed for 7 days.

Note | Regular issue | Vol 45, No. 11, 1997, pp.2253-2260
Published online, 1st January, 1970
DOI: 10.3987/COM-97-7935
Studies on Inhibitory Activity against Acetylcholinesterase of New Bisbenzylisoquinoline Alkaloid and Its Related Compounds

Tatsunori Ogino,* Takuji Yamaguchi, Toshitsugu Sato, Hiroshi Sasaki, Ko Sugama, Minoru Okada, and Masao Maruno

*Central Research Laboratory, Tsumura & Co., 3586 Yoshiwara, Ami-machi, Inashiki-gun, Ibaraki, 300-11, Japan


A new phenolic bisbenzylisoquinoline (BBI) alkaloids named 2’-N-norfangchinoline was isolated from the root of Stephania tetrandra S. MOORE along withfangchinoline (2) and atherospermoline (3). The chemical structure of 2’-N-norfangchinoline was proved to be 4 by spectral analyses and chemical methods. Moreover three phenolic BBI alkaloidal compounds, 2,2’-N,N-dinorfangchinoline (8), 2’-N-noratherospermoline (9), 2-N-norfangchinoline (10) were derived from tetradrine (1). And 12-O-acetyl antherospermoline (11) was obtained by partial acetylation of atherospermoline (3). Seven phenolic BBI compounds (2, 3, 4, 8, 9, 10, and 11) also have the inhibitory effect on acetylcholinesterase.