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■ Studies on Inhibitory Activity against Acetylcholinesterase of New Bisbenzylisoquinoline Alkaloid and Its Related Compounds

Tatsunori Ogino,* Takuji Yamaguchi, Toshitsugu Sato, Hiroshi Sasaki, Ko Sugama, Minoru Okada, and Masao Maruno

*Central Research Laboratory, Tsumura & Co., 3586 Yoshiwara, Ami-machi, Inashiki-gun, Ibaraki, 300-11, Japan

Abstract

A new phenolic bisbenzylisoquinoline (BBI) alkaloids named 2’-N-norfangchinoline was isolated from the root of Stephania tetrandra S. MOORE along withfangchinoline (2) and atherospermoline (3). The chemical structure of 2’-N-norfangchinoline was proved to be 4 by spectral analyses and chemical methods. Moreover three phenolic BBI alkaloidal compounds, 2,2’-N,N-dinorfangchinoline (8), 2’-N-noratherospermoline (9), 2-N-norfangchinoline (10) were derived from tetradrine (1). And 12-O-acetyl antherospermoline (11) was obtained by partial acetylation of atherospermoline (3). Seven phenolic BBI compounds (2, 3, 4, 8, 9, 10, and 11) also have the inhibitory effect on acetylcholinesterase.