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Paper | Regular issue | Vol 45, No. 10, 1997, pp.1967-1978
Published online, 1st January, 1970
DOI: 10.3987/COM-97-7931
Synthesis and Aromatization of Dihydropyrimidines Structurally Related to Calcium Channel Modulators of the Nifedipine-Type

Jean Jacques Vanden Eynde, Nancy Audiart, Valérie Canonne, Sophie Michel, Yves Van Haverbeke, and C. Oliver Kappe*

*Institute of Organic Chemistry, Karl-Franzens-University Graz, Heinrichstr. 28, A-8010 Graz, Austria


A series of 4-substituted ethyl 2-methoxy-6-methyl-1,4-dihydropyrimidine-5-carboxylates has been synthesized and was successfully aromatized to the corresponding pyrimidines with various oxidizing reagents. O-Demethylation of such pyrimidines provides a simple route to pyrimidinone derivatives which are otherwise difficult to obtain.