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Paper | Regular issue | Vol 45, No. 10, 1997, pp.1929-1935
Published online, 1st January, 1970
DOI: 10.3987/COM-97-7922
Investigation of the Reaction of 5-Bromonicotinic Acid with Certain Arylacetonitriles and LDA in THF

Anlai Wang and Edward R. Biehl*

*Southern Methodist University, P.O.Box 750314, Dallas, Texas 75275-0314, U.S.A.


The reaction of 5-bromonicotinic acid with various arylacetonitriles and LDA yields the corresponding 5-(α-arylcyanomethyl)nicotinic acids in good yields. These cyano acids can be oxidatively decyanated to the respective 5-aroylnicotinic acid in excellent yields.