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Paper | Regular issue | Vol 48, No. 2, 1998, pp.243-248
Published online, 1st January, 1970
DOI: 10.3987/COM-97-7921
A Facile Access to Benzo[c]phenanthridines via 4-Functionalized 3-Arylisoquinolines

Teresa Vicente, Esther Domínguez,* and María Jesús Villa

*Departamento de Química Orgánica, Facultad de Ciencias, Universidad de Pais, Vasco, P.O. Box 644, 48080-Bilbao, Basque Country, Spain

Abstract

4b,10b-trans-N-Benzyltetrahydrobenzo[c]phenanthridines have been synthesized by a short and efficient route from a 4-functionalized 3-aryltetrahydroisoquinoline. The 3-aryl-4-carboxymethyltetrahydroisoquinoline (5) and 4-formylmethyl derivative (7) were cyclodehydrated to the corresponding tetracycles.