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Note | Regular issue | Vol 45, No. 10, 1997, pp.2041-2043
Published online, 1st January, 1970
DOI: 10.3987/COM-97-7895
An Efficient Process of Ondansetron Synthesis

Moohi Yoo Kim,* Geun Jho Lim, Joong In Lim, Dong Sung Kim, Ik Yon Kim, and Jae Sung Yang

*Dong-A Pharmaceutical Co. LTd., Research Laboratories, 47-1, Sanggal-Ri, Kiheung-Up, Yongin-Si, Kyunggi-Do, 449-900, Korea


An efficient and practical two-step synthesis of ondansetron (1) was accomplished from readily available N-methyltetrahydrocarbazolone (2) via direct Mannich α-methylenation and alumina catalyzed Michael addition resulting in a 70% overall yield.