HETEROCYCLES
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Obituary
Zenichi Yoshida (1925-2023)
Zenichi Yoshida (1925-2023)
Professor. Zenichi Yoshida,
a member of the Honorary Advisors of HETEROCYCLES (1975-1998),
has passed away on May 4, 2023 at the age of 97.
I deeply express my regret over his death.
Kunio Ogasawara
Editor
May 11, 2023
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Note | Regular issue | Vol 45, No. 10, 1997, pp.2041-2043
Published online, 1st January, 1970■ An Efficient Process of Ondansetron Synthesis
Published online, 1st January, 1970
DOI: 10.3987/COM-97-7895
■ An Efficient Process of Ondansetron Synthesis
Moohi Yoo Kim,* Geun Jho Lim, Joong In Lim, Dong Sung Kim, Ik Yon Kim, and Jae Sung Yang
*Dong-A Pharmaceutical Co. LTd., Research Laboratories, 47-1, Sanggal-Ri, Kiheung-Up, Yongin-Si, Kyunggi-Do, 449-900, Korea
Abstract
An efficient and practical two-step synthesis of ondansetron (1) was accomplished from readily available N-methyltetrahydrocarbazolone (2) via direct Mannich α-methylenation and alumina catalyzed Michael addition resulting in a 70% overall yield.
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