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Note | Regular issue | Vol 48, No. 4, 1998, pp.743-747
Published online, 1st January, 1970
DOI: 10.3987/COM-97-7886
Synthesis of 1,3-Dialkyl- and 1,3-Diphenyl-5-cyano-2-thiouracil Derivatives

Lars F. Jalander* and Jan-Erik Lönnqvist

*Department of Organic Chemistry, Abo Akademi University, Biskopsgatan 8, FIN-20500 Abo, Finland


Nucleophilic vinylic substitutions of ethyl (E)- and (Z)-3-aryl-3-chloro-2-cyanopropenoates (1a) and (1b) with symmetrically substituted thioureas afforded, after spontaneous cyclisation, 1,3-dialkyl- and 1,3-diphenyl-5-cyano-2-thiouracil derivatives (3a-3h) in moderate to good yields.