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Note | Regular issue | Vol 45, No. 10, 1997, pp.1989-1997
Published online, 1st January, 1970
DOI: 10.3987/COM-97-7877
Synthesis and NMR-Investigation of Annelated Pyrrole Derivatives

Helmut Spreitzer,* Wolfgang Holzer, Christiane Puschmann, Andrea Pichler, Angelika Kogard, Klaus Tschetschkowitsch,Tatjana Heinze, Sabina Bauer, and Nejati Shabaz

*Institute of Pharmaceutical Chemistry, University of Vienna, Währinger Strasse 10, A-1090 Vienna, Austria


The synthesis of annelated pyrrole, namely isoindole derivatives by reaction of α,β-unsaturated ketones, benzo- and naphthoquinone monoketals with tosylmethyl isocyanide is described. Moreover, detailed NMR spectroscopic studies (1H, 13C) with the title compounds are presented.