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Paper | Regular issue | Vol 45, No. 8, 1997, pp.1551-1557
Published online, 1st January, 1970
DOI: 10.3987/COM-97-7847
Ring Transformation of Fused Pyridazines. VI. Construction of 3-(2-Pyridyl)indole Skeleton by Means of N-N Bond Cleavage Reaction of Fused Pyridazines with Ynamines

Ken-ichi Iwamoto,* Etsuo Oishi, Tomonobu Sano, Ayako Tsuchiya, Yumiko Suzuki, Takeo Higashino, and Akira Miyashita

*Schol of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Shizuoka 422-8526, Japan


We established a new N-N bond cleavage reaction of pyridazino[4,5-b]indoles with ynamines to form 3-(2-pyridyl)indoles. The latter are easily converted to 3-(2-piperidyl)indoles, which are key intermediates for the synthesis of indole alkaloids.